Antigen-Presenting Activity of Non-Langerhans Epidermal Cells in Contact Hypersensitivity Reactions
نویسندگان
چکیده
منابع مشابه
Antigen-presenting activity of non-Langerhans epidermal cells in contact hypersensitivity reactions.
Despite the critical role of the Langerhans cells in the induction of contact hypersensitivity reactions, non-Langerhans antigen-presenting cells in already sensitized individuals may play a role in the elicitation phase of a contact hypersensitivity reaction. Following epicutaneous challenge with antigens, the number of CD1+DR+ epidermal Langerhans cells increased in a time-dependent way and, ...
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Mice lacking epidermal Langerhans cells (LC) develop exaggerated contact-hypersensitivity (CHS) responses due to the absence of LC during sensitization/initiation. Examination of T cell responses reveals that the absence of LC leads to increased numbers of hapten-specific CD4 and CD8 T cells but does not alter cytokine expression or development of T regulatory cells. CHS responses and Ag-specif...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 1990
ISSN: 0300-9475,1365-3083
DOI: 10.1111/j.1365-3083.1990.tb02914.x